Fri Jan 10 2025

29 articles - From Friday Jan 03 2025 to Friday Jan 10 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

A Simple Endoscopic Score for Crohn's Disease (SES-CD) ≥ 7 Predicts Disease Progression.

SES-CD ≥ 7 predicts disease progression in mild CD. A score ≤ 6 may help identify patients less likely to progress and be part of the definition of mild CD.

Pubmed   Journal   ReadQx 

Alcohol-Related Liver Disease, Followed by Metabolic Dysfunction-Associated Steatotic Liver Disease, Emerges as the Fastest-Growing Aetiologies for Primary Liver Cancer in the United States.

The burden of PLC in the United States has risen in the past two decades, driven mainly by ALD and followed by MASLD. These findings offer policymakers an accurate assessment of the PLC burden and emphasise the need for targeted risk factor mitigation, especially regarding alcohol related policy.

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Experience With Dabigatran on Rate of Portal Vein Thrombosis Recanalization, Disease Progression and Survival.

On dabigatran, 47% of 119 patients achieved portal vein recanalization over 32 months of follow-up which was higher than the spontaneous RR (21.4%) in an untreated cohort. High Factor VIII Ag was a predictor of non-recanalization. Dabigatran was safe in cirrhosis (CP-A and B) while further work is needed in CP-C.

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Global Burden of Gallbladder Cancer Attributable to Modifiable Risk Factors.

Central obesity (29.7%; 8.7-49.5), gallstones (27.9%; 16.8-40.7), and physical inactivity (20.5%; 7.4-34.1) were identified as the leading contributors. Most GBC cases are preventable, with a large share linked to metabolic health conditions.

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Am J Gastroenterol

Global, regional, and national burden of primary liver cancer attributable to metabolic risks: an analysis of the Global Burden of Disease Study 1990-2021.

Primary liver cancer attributable to high BMI and/or high FPG imposes an increasingly substantial clinical burden on global public health, particularly in high SDI countries. Rapid growth trends are also found in middle-SDI countries.

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Novel Concepts on the Functional Neuroanatomy of the Anorectum: Implications for Anorectal Neuropathy and Neuromodulation Therapy.

This illustrated review provides a new understanding of the afferent and efferent pathways between the rectum, spinal cord, and brain, and a framework for clinical implications of anorectal neuropathy, such as anal sphincter or rectal sensory or rectal accommodation dysfunction, causing bowel problems. Insights into the functional neuroanatomy provide an improved mechanistic understanding of anorectal symptoms and could facilitate the development of neurophysiological tests such as translumbosacral anorectal magnetic stimulation and neuromodulation treatments such as sacral neuromodulation and translumbosacral neuromodulation treatment.

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Optimal population screening strategies for liver fibrosis associated with metabolic dysfunction-associated steatotic liver disease.

The proposed population risk stratification approach using the SAFE score is simpler and substantially more effective, yielding more subjects with liver fibrosis while requiring less resources compared to the currently recommended algorithm.

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Prevalence and Risk Factors of Spondyloarthritis Symptoms in a US-Based Multicenter Cohort of Patients with Inflammatory Bowel Disease.

A substantial number of IBD patients screen positive for SpA symptoms, indicating a potentially high burden of undiagnosed illness. Factors associated with SpA symptoms include older age, female sex, and more severe disease (based on increased number advanced therapies or prior surgery), whereas IBD phenotype does not independently increase the risk of a positive SpA screen. Further studies are needed to confirm these findings and better characterize SpA in IBD.

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Rebound in Fecal Testing, Colonoscopy Utilization, and Colorectal Neoplasia Detection During the COVID-19 Pandemic.

Findings may help guide organizations looking to improve CRC screening and minimize healthcare disparities related to national emergencies such as pandemics. Long-term studies are needed to evaluate how pandemic-related changes in CRC screening practices will impact future CRC outcomes.

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Reduced gastric mucosal nerve density in functional dyspepsia: clinical significance and functional correlation.

GMND was reduced in FD and inversely correlated with the symptom severity.

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The Effects of alfapump on Ascites Control and Quality of Life in Patients with Cirrhosis and Recurrent or Refractory Ascites.

The alfapump system effectively controlled ascites, which improved quality of life. It may be considered as an alternative to repeat TP in select patients with RA. Complication rates were similar to those expected in patients with RA.

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Gut

Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus.

Aspirin use may be an oncopreventive strategy to reduce PC risk in patients with T2DM. Further studies are warranted to validate the study findings.

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Construction of exosome non-coding RNA feature for non-invasive, early detection of gastric cancer patients by machine learning: a multi-cohort study.

Our proposed serum exosome ncRNA feature provides a promising liquid biopsy approach for enhancing the early diagnosis of GC.

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J Hepatol

Host hepatocyte senescence determines the success of hepatocyte transplantation in a mouse model of liver injury.

The host niche impacts the initial engraftment and long-term function of transplanted hepatocytes. Targeting paracrine senescence may be a way to improve donor hepatocyte function, optimise therapy and guide translation into the clinics. Impact and implications Hepatocyte transplantation has shown promise for genetic diseases but has limited efficacy for acute and severe liver injury. Poor engraftment and functionality inhibit wide-spread clinical application. We show that host senescence provides a required non-competitive niche for donor hepatocytes to repopulate the recipient liver, but can paradoxically, negatively impact donor function. These findings demonstrate a requirement for a clear understanding of the host niche prior to cell transfusion. This has significant implications not only for hepatocellular therapies, but also when developing and optimising any pre-clinical and clinical cell therapies.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Heads or Tails in the Treatment of Functional Dyspepsia-Does the Side of the Coin Matter?

Pubmed   Journal   ReadQx 

Editorial: Striving for Equitable Care in Ulcerative Colitis.

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Management of Perianal Fistulizing Crohn's Disease According to Principles of Wound Repair.

This review provides a comprehensive overview of the phases of wound repair and specific treatment strategies for each to provide clinicians with a rational framework for managing PFCD.

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Gastroenterology

Reimagining Liver Cancer Allocation: Defining a New Vision.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

An Unusual Cause of Rectal Perforation.

Pubmed   Journal   ReadQx 

Force-Feeding: Traumatic Nasoenteric Tube Placement Complicated by Pneumothorax.

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Innovative Use of a Condom for Safe Removal of a Sharp Foreign Body Impacted at the Esophageal Inlet.

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Mesenteric Arteriovenous Fistula: A Rare Cause of Gastrointestinal Bleeding in Children.

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Removal Of A Chronically Embedded Coin From The Esophageal Wall Using The "Stent-In-Stent" Approach In A Child.

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Clin Gastroenterol Hepatol

Twin Pregnancies in Inflammatory Bowel Disease are Associated with Increased Adverse Outcomes.

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J Hepatol

The use of immunotherapy pre-liver transplant.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Heads or Tails in the Treatment of Functional Dyspepsia-Does the Side of the Coin Matter? Authors' Reply.

Pubmed   Journal   ReadQx 

Editorial: Striving for Equitable Care in Ulcerative Colitis-Authors' Reply.

Pubmed   Journal   ReadQx 

J Hepatol

Optimal Timing To Initiate Antiviral Prophylaxis of MTCT: More Required to Be Done.

Pubmed   Journal   ReadQx 

Response to: Rethinking Methodology and Data Integrity in Mendelian Randomization: Insights from Air Pollution and MASLD Research.

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